4-Methylmorpholine → HCID 178446462, compound

Participants

Reaction Steps

The title compound was prepared following the procedure as described for Example-1 using 2-[(3,5-dichloropyridin-4-yl)amino]-7,7-dimethyl-7,8-dihydro-1H-furo[3,2-e]benzimidazole-5-carboxylic acid (Intermediate-3, 0.050 g, 0.127 mmol), O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate (0.082 g, 0.225 mmol), N-methyl morpholine (0.5 mL), DMF (1.0 mL), THF (5.0 mL) and n-pentyl amine (0.022 g, 0.254 mmol) to afford 0.012 g of the desired product. 1HNMR (DMSO-d6): δ 1.29 (t, J=6.3 Hz, 3H), 1.64 (s, 3H), 1.71 (s, 6H), 1.91 (s, 3H), 3.42 (s, 2H), 3.68-3.74 (m, 2H), 7.62 (s, 1H), 8.10 (m, 1H), 8.84 (s, 2H), 11.23 (s, 1H), 11.81 (s, 1H); MS [M+H]+: 462.43.

Provenance & Evidence