Dimethylformamide → HCID 178464695, compound

Participants

Reaction Steps

The title compound was prepared following the procedure as described for Example-1 using 2-[(3,5-dichloropyridin-4-yl)amino]-7,7-dimethyl-7,8-dihydro-1H-furo[3,2-e]benzimidazole-5-carboxylic acid (Intermediate-3, 0.050 g, 0.127 mmol), O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate (0.081 g, 0.254 mmol), N-methyl morpholine (0.5 mL), DMF (1.0 mL), THF (5.0 mL) and R-(−)-1-cyclohexyl ethyl amine (0.032 g, 0.254 mmol) to afford 0.015 g of the desired product. 1HNMR (DMSO-d6): δ 1.09 (d, J=6.3 Hz, 3H), 1.14-1.23 (m, 4H), 1.40 (s, 3H), 1.48 (s, 3H), 1.52-1.63 (m, 7H), 2.72 (s, 2H), 3.84 (m, 1H), 7.21 (s, 1H), 7.62 (d, J=7.8 Hz, 1H), 8.40 (s, 2H), 11.00 (s, 2H); MS [M+H]+: 502.45.

Provenance & Evidence