4-Methylmorpholine → HCID 178446461, compound

Participants

Reaction Steps

The title compound was prepared following the procedure as described for Example-1 using 2-[(2,6-dichlorophenyl)amino]-7,7-dimethyl-7,8-dihydro-1H-furo[3,2-e]benzimidazole-5-carboxylic acid (Intermediate-6, 0.070 g, 0.178 mmol), O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate (0.114 g, 0.306 mmol), N-methyl morpholine (1.0 mL), DMF (1.0 mL), THF (5.0 mL) and pentan-1-amine (0.031 g, 0.356 mmol) to afford 0.025 g of the desired product. 1HNMR (DMSO-d6): δ 0.880 (m, 3H), 1.23-1.33 (m, 8H), 1.49 (s, 6H), 3.03 (s, 2H), 7.19 (m, 1H), 7.32 (s, 1H), 7.50 (d, J=7.8 Hz, 2H), 7.71 (s, 1H), 10.50-11 (s, 2H); MS [M+H]+: 461.55.

Provenance & Evidence