4-Methylmorpholine → HCID 178422754, compound

Participants

Reaction Steps

The title compound was prepared following the procedure as described for Example-1 using 2-[(3,5-dichloropyridin-4-yl)amino]-7,7-dimethyl-7,8-dihydro-1H-furo[3,2-e]benzimidazole-5-carboxylic acid (Intermediate-3, 0.100 g, 0.254 mmol), O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate (0.163 g, 0.509 mmol), N-methyl morpholine (1.0 mL), DMF (1.5 mL), THF (7.0 mL) and 4-trifluoro methyl aniline (0.082 g, 0.509 mmol) to afford 0.020 g of the desired product. 1HNMR (DMSO-d6): δ 1.58 (s, 6H), 3.07 (s, 2H), 7.25 (s, 1H), 7.72 (d, J=8.1 Hz, 2H), 7.90 (d, J=8.4 Hz, 2H), 8.45 (s, 2H), 9.91 (s, 1H), 10.99 (s, 1H), 11.55 (s, 1H); MS [M+H]+: 536.22.

Provenance & Evidence