Cyclohexylamine → HCID 178422225, compound

Participants

Reaction Steps

The title compound was prepared following the procedure as described for Example-1 using 2-[(3,5-dichloropyridin-4-yl)amino]-7-methyl-1H-furo[3,2-e]benzimidazole-5-carboxylic acid (Intermediate-8, 0.050 g, 0.132 mmol), O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate (0.085 g, 0.265 mmol), THF (5.0 mL), DMF (1.0 mL) and cyclohexyl amine (0.026 g, 0.265 mmol) to afford 0.020 g of the desired product. 1HNMR (DMSO-d6): δ 1.23 (s, 3H), 1.36 (t, J=9.6 Hz, 3H), 1.71 (m, 2H), 1.88 (m, 2H), 2.50 (s, 3H), 3.84 (m, 1H), 6.62 (s, 1H), 7.31 (m, 1H), 7.75 (d, J=7.8 Hz, 1H), 8.44 (s, 2H), 11.23 (s, 1H), 11.74 (s, 1H); MS [M+H]+: 458.38.

Provenance & Evidence