Cyclohexylamine → HCID 178422224, compound

Participants

Reaction Steps

The title compound was prepared following the procedure as described for Example-1 using 2-[(2,6-dichlorophenyl)amino]-7-methyl-1H-furo[3,2-e]benzimidazole-5-carboxylic acid (Intermediate-9, 0.050 g, 0.132 mmol), O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate (0.085 g, 0.265 mmol), TEA (1 mL), THF (5.0 mL), DMF (1.0 mL) and cyclohexyl amine (0.026 g, 0.265 mmol) to afford 0.008 g of the desired product. 1HNMR (DMSO-d6): δ 1.23-1.30 (m, 2H), 1.31-1.36 (m, 4H), 1.89 (m, 4H), 3.85 (m, 1H), 4.19 (s, 3H), 6.74 (s, 1H), 7.41-7.94 (m, 4H), 9.07 (s, 1H), 11.00-12.00 (s, 2H).

Provenance & Evidence