Dimethylformamide → HCID 178422223, compound

Participants

Reaction Steps

The title compound was prepared following the procedure as described for Example-1 using 2-[(2-chlorophenyl)amino]-7-methyl-1H-furo[3,2-e]benzimidazole-5-carboxylic acid (Intermediate-11, 0.050 g, 0.146 mmol), O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate (0.094 g, 0.293 mmol), TEA (1.0 mL), DMF (1.0 mL), THF (5.0 mL) and cyclohexyl amine (0.029 g, 0293 mmol) to afford 0.016 g of the desired product. 1HNMR (DMSO-d6): δ 1.23-1.39 (m, 4H), 1.39-1.52 (m, 1H), 1.58 (m, 1H), 1.74 (m, 2H), 1.90 (m, 2H), 3.33 (m, 3H), 3.88 (m, 1H), 6.85 (s, 1H), 7.05 (m, 1H), 7.40 (t, J=7.2 Hz, 1H), 7.50 (d, J=7.8 Hz, 1H), 7.61-7.70 (m, 2H), 8.62 (s, 1H), 10.20 (s, 1H), 11.25 (s, 1H); MS [M+H]+: 423.41.

Provenance & Evidence