Dimethylformamide → HCID 178421857, compound

Participants

Reaction Steps

The title compound was prepared following the procedure as described for Example-1 using 2-[(3,5-dichloropyridin-4-yl)amino]-7,7-dimethyl-7,8-dihydro-1H-furo[3,2-e]benzimidazole-5-carboxylic acid (Intermediate-3, 0.050 g, 0.121 mmol), O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate (0.081 g, 0.255 mmol), N-methyl morpholine (0.5 mL), DMF (1.0 mL), THF (5.0 mL) and 1R,2R,3R,5(−)-isopinocampheyl amine (0.039 g, 0.254 mmol) to afford 0.008 g of the desired product. 1HNMR (DMSO-d6): δ 1.03 (s, 3H), 1.08 (d, J=6.9 Hz, 3H), 1.22 (s, 6H), 1.50 (s, 7H), 1.83-1.85 (m, 2H), 1.95 (m, 1H), 3.02 (s, 2H), 4.26 (m, 1H), 7.21 (s, 1H), 7.70 (d, J=8.4 Hz, 1H), 8.43 (s, 2H), 10.91 (brs, 1H), 11.42 (s, 1H); MS [M+H]+: 528.39.

Provenance & Evidence