Dimethylformamide → HCID 178422732, compound

Participants

Reaction Steps

The title compound was prepared following the procedure as described for Example-1 using 2-[(3,5-dichloropyridin-4-yl)amino]-7,7-dimethyl-7,8-dihydro-1H-furo[3,2-e]benzimidazole-5-carboxylic acid (Intermediate-3, 0.080 g, 0.203 mmol), O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate (0.130 g, 0.406 mmol), TEA (0.5 mL), DMF (1.0 mL), THF (5.0 mL) and adamantly amine (0.092 g, 0.609 mmol) to afford 0.015 g of the desired product. 1HNMR (DMSO-d6): δ 1.49 (s, 6H), 1.66 (s, 6H), 2.01 (s, 9H), 3.01 (s, 2H), 7.19 (s, 1H), 7.51 (s, 1H), 8.42 (s, 2H), 10.87 (s, 1H), 11.39 (s, 1H); MS [M+H]+: 526.38.

Provenance & Evidence