2-Butanamine, 3,3-dimethyl- → HCID 178422227, compound

Participants

Reaction Steps

The title compound was prepared following the procedure described for Example-1 using 2-[(3,5-dichloropyridin-4-yl)amino]-7-methyl-1H-furo[3,2-e]benzimidazole-5-carboxylic acid (Intermediate-8, 0.050 g, 0.132 mmol), propyl phosphonic anhydride (0.084 g, 0.265 mmol), TEA (0.027 g, 0.265 mmol), DMF (3.0 mL) and 3,3-dimethyl-2-butyl amine (0.027 g, 0.318 mmol) to afford 0.015 g of the desired product. 1HNMR (DMSO-d6): δ 0.85 (t, J=6.9 Hz, 3H), 0.96 (s, 6H), 1.11 (d, J=6.9 Hz, 3H), 2.50 (m, 3H), 3.95-3.97 (m, 1H), 6.65 (s, 1H), 7.35 (s, 1H), 7.63 (d, J=9.0 Hz, 1H), 8.45 (s, 2H), 11.20 (s, 1H), 11.80 (s, 1H); MS [M+H]+: 460.34.

Provenance & Evidence