Diisopropylethylamine → HCID 178422770, compound

Participants

Reaction Steps

The title compound was prepared by following the procedure described for Example-121 using 2-[(2-chloro-6-fluorophenyl)amino]-7,7-dimethyl-7,8-dihydro-1H-furo[3,2-e]benzimidazole-5-carboxylic acid (Intermediate-15, 0.100 g, 0.266 mmol), COMU (0.284 g, 0.663 mmol), DIPEA (0.085 g, 0.658 mmol), 2-amino-5-(trifluoromethyl)pyridine 1-oxide (Intermediate-41, 0.052 g, 0.292 mmol), DMF (5 mL), iron powder (0.100 g) and acetic acid (5.0 mL) to afford 0.012 g of the desired product. 1HNMR (DMSO-d6): δ 1.57 (s, 6H), 3.12 (s, 2H), 7.33 (m, 3H), 7.54 (s, 1H), 8.23 (d, J=8.7 Hz, 1H), 8.48 (d, J=8.70 Hz, 1H), 8.57 (s, 1H), 10.47 (s, 1H), 11.00-12.00 (s, 2H); MS [M]+: 520.18.

Provenance & Evidence