3-(Trifluoromethyl)aniline → HCID 178422752, compound

Participants

Reaction Steps

The title compound was prepared by following the procedure as described for Example-137 using methyl 2-(2-chloro-6-fluorobenzamido)-7,7-dimethyl-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxylate (Intermediate-51, 0.200 g, 0.477 mmol), 3-trifloromethyl aniline (0.230 g, 1.43 mmol), trimethyl aluminium (2M solution in toluene) (0.5 mL) and dry toluene (5.0 mL). The reaction mass was stirred at RT for 4-5 h. The obtained crude was purified on preparative TLC using 4% DCM:MeOH as solvent system to afford 0.011 g of the desired product. 1HNMR (DMSO-d6): δ 1.57 (s, 6H), 3.14 (s, 2H), 6.30 (s, 1H), 7.43 (d, J=7.8 Hz, 2H), 7.56-7.70 (m, 4H), 7.86 (q, J=6.3 Hz, 1H), 8.15 (bs, 2H), 9.71 (s, 1H); MS [M+H]+: 547.06.

Provenance & Evidence