反应详情

The title compound was prepared following the procedure described for Example-137 using methyl 2-((2-chlorobenzyl)amino)-7,7-dimethyl-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxylate (Intermediate-52, 0.200 g, 0.519 mmol), 3-trifluoromethyl aniline (0.167 g, 1.038 mmol), trimethyl aluminium (2M solution in toluene) (0.5 mL) and dry toluene (5.0 mL). The obtained crude was purified by column chromatography eluting with 0.5% DCM:MeOH to afford 0.0650 g of the desired product. 1HNMR (DMSO-d6): δ 1.57 (s, 6H), 3.16 (s, 2H), 7.00 (d, J=6 Hz, 2H), 7.30-7.42 (m, 2H), 7.44-7.64 (m, 6H), 7.72 (d, J=7.8 Hz, 1H), 8.35 (s, 1H), 9.96 (s, 1H), 10.90 (s, 1H); [M+H]+: 515.19.

1. customThe title compound was prepared
2. customThe obtained crude
3. customwas purified by column chromatography
4. washeluting with 0.5% DCM