2-Fluoro-5-(trifluoromethyl)aniline → HCID 178422788, compound

Participants

Reaction Steps

The title compound was prepared following the procedure described for Example-137 using methyl 2-((2-chlorobenzyl)amino)-7,7-dimethyl-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxylate (Intermediate-52, 0.200 g, 0.519 mmol), 2-fluoro-5-trifluoromethyl aniline (0.237 g, 1.0389 mmol), trimethyl aluminium (2M solution in toluene) (0.5 mL) and dry toluene (5.0 mL). The obtained crude was purified by column chromatography eluting with 0.5% DCM:MeOH to afford 0.013 g of the desired product. 1HNMR (DMSO-d6): δ 1.55 (s, 6H), 3.14 (s, 2H), 4.61 (m, 2H), 7.32 (m, 2H), 7.40 (m, 1H), 7.49-7.62 (m, 5H), 7.69 (m, 1H), 8.93 (d, J=6.3 Hz, 1H), 10.34 (bs, 1H), 11.00 (bs, 1H). [M+H]+: 533.08.

Provenance & Evidence