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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1898412Generated: October 30, 2026

Hydrochloric Acid → HCID 178422756, compound

https://huagongshe.com/reaction/1898412

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantHCID 178422755HCID 178422755—
SolventTetrahydrofuranHCID 8028—
ProductHCID 178422756HCID 178422756186.9%

Reaction Steps

To a solution of 2-[(2-chloro-6-fluorophenyl)amino]-7,7-dimethyl-N-[4-(trifluoromethyl)phenyl]-7,8-dihydro-1H-furo[3,2-e]benzimidazole-5-carboxamide (Example-107, 0.100 g) in THF was added HCl saturated DEE. The reaction mass was refluxed for 3 h. The reaction mass was filtered. The obtained residue was washed with pentane and DEE to afford 0.100 g of the desired product.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08519149B2
Source datasetuspto-grants-2013_08
ORD IDord-0b2e88a8eb014518b5c8cce87d47ed0f
Source noteuspto-grants-2013_08