HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 178422756, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 178422755 | HCID 178422755 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 178422756 | HCID 178422756 | 186.9% |
Reaction Steps
To a solution of 2-[(2-chloro-6-fluorophenyl)amino]-7,7-dimethyl-N-[4-(trifluoromethyl)phenyl]-7,8-dihydro-1H-furo[3,2-e]benzimidazole-5-carboxamide (Example-107, 0.100 g) in THF was added HCl saturated DEE. The reaction mass was refluxed for 3 h. The reaction mass was filtered. The obtained residue was washed with pentane and DEE to afford 0.100 g of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08519149B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-0b2e88a8eb014518b5c8cce87d47ed0f |
| Source note | uspto-grants-2013_08 |