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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1898416Generated: November 2, 2026

Trifluoroacetic acid → HCID 178425061, compound

https://huagongshe.com/reaction/1898416

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
ReactantHCID 178425058HCID 178425058—
SolventTetrahydrofuranHCID 8028—
ProductHCID 178425061HCID 178425061—

Reaction Steps

To a solution of 2-[(2-chloro-6-methylphenyl)amino]-N-[2-fluoro-5-(trifluoromethyl)phenyl]-7,7-dimethyl-7,8-dihydro-1H-furo[3,2-e]benzimidazole-5-carboxamide (Example-110, 0.100 g) in THF was added trifluoro acetic acid (3 eq.) The reaction mass was refluxed for 3 h. The reaction mass was filtered and obtained residue was washed with DEE to afford 0.100 g desired product.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08519149B2
Source datasetuspto-grants-2013_08
ORD IDord-2a8ffd15a35242c38ff5ea3e7bfe25e5
Source noteuspto-grants-2013_08