HRID1898417

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID971

Oxalic acid

C2H2O4

结构：Cc1cccc(Cl)c1Nc1nc2cc(C(=O)Nc3cc(C(F)(F)F)ccc3F)c3c(c2[nH]1)CC(C)(C)O3

HCID178425058

未命名化合物

PRODUCTS

生成物

结构：Cc1cccc(Cl)c1Nc1nc2cc(C(=O)Nc3cc(C(F)(F)F)ccc3F)c3c(c2[nH]1)CC(C)(C)O3.O=C(O)C(=O)O

HCID178425062

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID180

Acetone

C3H6O

PROCEDURE

实验过程

To a solution of 2-[(2-chloro-6-methylphenyl)amino]-N-[2-fluoro-5-(trifluoromethyl)phenyl]-7,7-dimethyl-7,8-dihydro-1H-furo[3,2-e]benzimidazole-5-carboxamide (Example-110, 0.100 g) in acetone was added oxalic acid. The reaction mass was refluxed for 3 h. The reaction mass was filtered and obtained residue was washed with DEE to afford 0.100 g desired product.

WORKUP

后处理

temperatureThe reaction mass was refluxed for 3 h
filtrationThe reaction mass was filtered
customobtained residue
washwas washed with DEE

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d862f6e9208448fdb43c915cc123e679
来源数据集: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08519149B2
来源说明: uspto-grants-2013_08

反应 SMILES

[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[NH:9][C:10]1[NH:11][C:12]2[C:18]3[CH2:19][C:20]([CH3:23])([CH3:22])[O:21][C:17]=3[C:16]([C:24]([NH:26][C:27]3[CH:32]=[C:31]([C:33]([F:36])([F:35])[F:34])[CH:30]=[CH:29][C:28]=3[F:37])=[O:25])=[CH:15][C:13]=2[N:14]=1.[C:38]([OH:43])(=[O:42])[C:39]([OH:41])=[O:40]>CC(C)=O>[C:38]([OH:43])(=[O:42])[C:39]([OH:41])=[O:40].[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[NH:9][C:10]1[NH:11][C:12]2[C:18]3[CH2:19][C:20]([CH3:22])([CH3:23])[O:21][C:17]=3[C:16]([C:24]([NH:26][C:27]3[CH:32]=[C:31]([C:33]([F:36])([F:34])[F:35])[CH:30]=[CH:29][C:28]=3[F:37])=[O:25])=[CH:15][C:13]=2[N:14]=1