5-Amino-2-(trifluoromethyl)pyridine → HCID 178425054, Verbindung

Beteiligte Stoffe

Reaktionsschritte

The title compound was prepared by following the procedure as described for Example-137 using methyl 2-[(2-chloro-6-methylphenyl)amino]-7,7-dimethyl-7,8-dihydro-1H-furo[3,2-e]benzimidazole-5-carboxylate (Step-1 of Intermediate-35, 0.150 g, 0.301 mmol), 6-(trifluoromethyl)pyridine-3-amine (0.067 g, 0.451 mmol), trimethyl aluminium (2M solution in toluene) (1 mL) and dry toluene (5.0 mL) to afford 0.075 g of the desired product. 1HNMR (DMSO-d6): δ 1.56 (s, 6H), 2.23 (s, 3H), 3.09 (s, 2H), 7.23-7.31 (m, 2H), 7.40 (d, J=7.8 Hz, 1H), 7.47 (s, 1H), 7.87 (d, J=8.7 Hz, 1H), 8.45 (d, J=8.4 Hz, 1H), 8.98 (s, 1H), 9.10 (bs, 1H), 10.08 (s, 1H), 10.90 (bs, 1H); MS [M]+: 516.16.

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