Sodium hydride → HCID 178493443, compound

Participants

Reaction Steps

The title compound was prepared by following the procedure as described for Example-156 using N′-hydroxy-3,5-dimethoxybenzimidamide (Intermediate-54, 0.075 g, 0.30 mmol), sodium hydride (0.021 g, 0.51 mmol), methyl 2-((2-chloro-6-chlorophenyl)amino)-7,7-dimethyl-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxylate (Step-1 of Intermediate-6, 0.100 g, 0.255 mmol) and THF to afford 0.029 g of the desired product. 1HNMR (DMSO-d6): δ 1.29 (d, J=7.8 Hz, 6H), 3.09 (s, 2H), 3.85 (s, 6H), 6.58 (s, 1H), 7.30 (m, 3H), 7.44 (d, 1H), 7.78 (s, 1H). MS [M+H]+: 552.09.

Provenance & Evidence