Trimethylaluminum → HCID 178425053, compound

Participants

Reaction Steps

The title compound was prepared following the procedure described for Example-137 using methyl 2-[(2-chloro-6-methylphenyl)amino]-7,7-dimethyl-7,8-dihydro-1H-furo[3,2-e]benzimidazole-5-carboxylate (Step-1 of Intermediate-35, 0.100 g, 0.207 mmol) and 2-amino-5-trifluoromethylpyridine-N-oxide (Intermediate-41, 0.053 g, 0.301 mmol), trimethyl aluminium (2M solution in toluene) (1 mL) and dry toluene (5.0 mL) to afford 0.030 g of the desired product. 1HNMR (DMSO-d6): δ 1.56 (s, 6H), 2.25 (s, 3H), 3.13 (s, 2H), 7.26-7.33 (m, 2H), 7.43 (d, J=6.9 Hz, 1H), 7.53 (s, 1H), 7.79 (d, J=6.9 Hz, 1H), 8.68 (d, J=9.3 Hz, 1H), 8.94 (s, 1H), 9.20 (s, 1H), 11.02 (s, 1H), 12.26 (s, 1H); MS [M+H]+: 532.11.

Provenance & Evidence