3-Amino-2-fluorobenzotrifluoride → HCID 178425050, compound

Participants

Reaction Steps

The title compound was prepared by following the procedure as described for Example-137 using methyl 2-[(2-chloro-6-methylphenyl)amino]-7,7-dimethyl-7,8-dihydro-1H-furo[3,2-e]benzimidazole-5-carboxylate (Step-1 of Intermediate-35, 0.100 g, 0.207 mmol) and 2-fluoro-3-trifluoromethyl aniline (0.044 g, 0.301 mmol), trimethyl aluminium (2M solution in toluene) (1 mL) and dry toluene (5.0 mL) to afford 0.025 g of the desired product. 1HNMR (DMSO-d6): δ 1.56 (s, 6H), 2.25 (s, 3H), 3.14 (s, 2H), 7.23-7.33 (m, 2H), 7.39-7.49 (m, 3H), 7.54 (s, 1H), 8.77 (m, 1H), 9.11 (s, 1H), 10.22 (s, 1H), 11.01 (s, 1H): MS [M−H]−: 531.08.

Provenance & Evidence