5-Amino-2-(trifluoromethyl)pyridine → HCID 178422772, compound

Participants

Reaction Steps

The title compound was prepared by following the procedure as described for Example-137 using methyl 2-[(2,6-dichlorophenyl)amino]-7,7-dimethyl-7,8-dihydro-1H-furo[3,2-e]benzimidazole-5-carboxylate (Step-1 of Intermediate-6, 0.200 g, 0.493 mmol) and 6-(trifluoromethyl)pyridin-3-amine (0.119 g, 0.740 mmol), trimethyl aluminium (2M solution in toluene) (0.071 g, 0.986 mmol) and dry toluene (5.0 mL) to afford 0.100 g of the desired product. 1HNMR (DMSO-d6): δ 1.58 (s, 6H), 3.09 (s, 2H), 7.39 (m, 3H), 7.53 (m, 1H), 7.89 (d, J=8.4 Hz, 1H), 8.46 (d, J=9.0 Hz, 1H), 8.99 (s, 1H), 10.07 (s, 1H), 10.94 (s, 2H); MS [M]+: 536.17.

Provenance & Evidence