3-Amino-2-fluorobenzotrifluoride → HCID 178422753, compound

Participants

Reaction Steps

The title compound was prepared following the procedure described for Example-137 using methyl 2-[(2-chloro-6-fluorophenyl)amino]-7,7-dimethyl-7,8-dihydro-1H-furo[3,2-e]benzimidazole-5-carboxylate (Step-1 of Intermediate-15, 0.100 g, 0.256 mmol), 2-fluoro-3-(trifluoromethyl)aniline (0.068 g, 0.379 mmol), trimethyl aluminium (2M solution in toluene) (0.5 mL) and dry toluene (5.0 mL) to afford 0.050 g of the desired product. 1HNMR (DMSO-d6): δ 1.56 (s, 6H), 3.13 (s, 2H), 7.32 (m, 2H), 7.42-7.45 (m, 4H), 8.76 (m, 1H), 10.20 (s, 1H), 11.20 (s, 2H); MS [M+H]+: 537.19.

Provenance & Evidence