Methanesulfonic Acid → HCID 178422757, compound

Participants

Reaction Steps

To a solution of 2-[(2-chloro-6-fluorophenyl)amino]-7,7-dimethyl-N-[4-(trifluoromethyl)phenyl]-7,8-dihydro-1H-furo[3,2-e]benzimidazole-5-carboxamide (Example-107, 0.100 g) in acetone was added methane sulphonic acid. The reaction mass was refluxed for 3 h followed by stirring at RT for 18 h. The reaction mass was filtered and the obtained residue was washed with DEE to afford 0.080 g of the desired product. 1HNMR (DMSO-d6): δ 1.59 (s, 6H), 2.30 (s, 3H), 3.19 (s, 2H), 7.57 (m, 3H), 7.64 (s, 1H), 7.73 (d, J=8.4 Hz, 2H), 7.93 (d, J=8.7 Hz, 2H), 10.03 (s, 1H), 12.0 (br, 3H).

Provenance & Evidence