5-Amino-2-(trifluoromethyl)pyridine → HCID 178422773, compound

Participants

Reaction Steps

The title compound was prepared by following the procedure described for Example-137 by using methyl 2-[(2-chloro-6-fluorophenyl)amino]-7,7-dimethyl-7,8-dihydro-1H-furo[3,2-e]benzimidazole-5-carboxylate (Step-1 of Intermediate-15, 0.100 g, 0.256 mmol), 6-(trifluoromethyl)pyridin-3-amine (0.062 g, 0.387 mmol), trimethyl aluminium (2M solution in toluene) (0.5 mL), dry toluene (5.0 mL) to afford 0.013 g of the desired product. 1HNMR (DMSO-d6): δ 1.58 (s, 6H), 3.33 (s, 2H), 7.33-7.41 (m, 4H), 7.89 (d, J=9.0 Hz, 1H), 8.47 (d, J=6.6 Hz, 1H), 9.00 (s, 1H), 10.09 (s, 1H), 11.20 (br s, 2H); MS [M+H]+: 520.11

Provenance & Evidence