4-Fluoro-3-(trifluoromethyl)aniline → HCID 178422778, compound

Participants

Reaction Steps

The title compound was prepared following the procedure described for Example-137 by using methyl 2-[(3,5-dichloropyridin-4-yl)amino]-7,7-dimethyl-7,8-dihydro-1H-furo[3,2-e]benzimidazole-5-carboxylate (Step-1 of Intermediate-3, 0.100 g, 0.245 mmol), 4-fluoro-3-(trifluoromethyl)aniline (0.064 g, 0.357 mmol), trimethyl aluminium (2M solution in toluene) (0.5 mL), dry toluene (5.0 mL) at room temperature to afford 0.048 g of the desired product. 1HNMR (DMSO-d6): δ 1.57 (s, 6H), 3.06 (s, 2H), 7.24 (s, 1H), 7.51 (t, J=9.6 Hz, 1H), 7.84 (m, 1H), 8.30 (d, J=4.2 Hz, 1H), 8.45 (s, 2H), 9.84 (s, 1H), 11.99 (br s, 1H), 11.53 (br s, 1H); MS [M+H]+: 554.54.

Provenance & Evidence