2-Chloro-p-toluidine → HCID 178426549, compound

Participants

Reaction Steps

The title compound was prepared following the procedure described for Example-137 by using methyl 2-[(3,5-dichloropyridin-4-yl)amino]-7,7-dimethyl-7,8-dihydro-1H-furo[3,2-e]benzimidazole-5-carboxylate (Step-1 of Intermediate-3, 0.100 g, 0.245 mmol), 2-chloro-4-methylaniline (0.052 g, 0.361 mmol), trimethyl aluminium (2M solution in toluene) (0.5 mL), dry toluene (5.0 mL) at room temperature to afford 0.030 g of the desired product. 1HNMR (DMSO-d6): δ 1.55 (s, 6H), 2.26 (s, 3H), 3.08 (s, 2H), 7.16 (t, J=7.8 Hz, 1H), 7.30 (s, 1H), 7.36 (s, 1H), 8.43 (s, 2H), 8.46 (s, 1H), 10.09 (s, 1H), 10.99 (br s, 1H), 11.52 (br s, 1H); MS [M+H]+: 517.97.

Provenance & Evidence