Sulfuric Acid → HCID 178425063, compound

Participants

Reaction Steps

To a solution of 2-[(2-chloro-6-methylphenyl)amino]-N-[2-fluoro-5-(trifluoromethyl)phenyl]-7,7-dimethyl-7,8-dihydro-1H-furo[3,2-e]benzimidazole-5-carboxamide (Example-110, 0.100 g) in acetone was added of sulphuric acid. The reaction mass was refluxed for 3 h. The reaction mass was filtered and obtained residue was washed with DEE to afford 0.081 g desired product. 1HNMR (DMSO-d6): 6 1HNMR (DMSO-d6): δ 1.60 (s, 6H), 2.33 (s, 3H), 3.24 (s, 2H), 7.47 (m, 2H), 7.58 (m, 3H), 7.72 (s, 1H), 8.85 (d, J=5.4 Hz, 1H), 10.24 (s, 1H), 11.0 (br, 2H); 13 (br s, 1H).

Provenance & Evidence