Trimethylaluminum → HCID 178422737, compound

Participants

Reaction Steps

The title compound was prepared following the procedure described for Example-137 by using methyl 2-[(3,5-dichloropyridin-4-yl)amino]-7,7-dimethyl-7,8-dihydro-1H-furo[3,2-e]benzimidazole-5-carboxylate (Step-1 of Intermediate-3, 0.100 g, 0.245 mmol), 5-cyclopropyl-2-fluoroaniline (0.053 g, 0.357 mmol), trimethyl aluminium (2M solution in toluene) (0.5 mL), dry toluene (5.0 mL) at room temperature to afford 0.075 g of the desired product. 1HNMR (DMSO-d6): δ 0.62 (d, J=6.3 Hz, 2H), 0.95 (d, J=8.4 Hz, 2H), 1.55 (s, 6H), 1.91 (m, 1H), 3.09 (s, 2H), 6.82 (m, 1H), 7.17 (t, J=10.5 Hz, 1H), 7.30 (s, 1H), 8.19 (d, J=5.7 Hz, 1H), 8.45 (s, 2H), 9.95 (s, 1H), 10.99 (s, 1H), 11.56 (br s, 1H); MS [M+H]+: 526.12.

Provenance & Evidence