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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1898471Generated: November 2, 2026

HCID 178422781, compound → HCID 178422782, compound

https://huagongshe.com/reaction/1898471

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 178422781HCID 178422781—
SolventTetrahydrofuranHCID 8028—
ProductHydrochloric AcidHCID 313—
ProductHCID 178422782HCID 178422782182.6%

Reaction Steps

The title compound was prepared following the procedure described for Example-146 by using 2-[(2-chloro-6-fluorophenyl)amino]-N-[4-fluoro-3-(trifluoromethyl)phenyl]-7,7-dimethyl-7,8-dihydro-1H-furo[3,2-e]benzimidazole-5-carboxamide (Example-104, 0.100 g), THF, conc.HCl to afford 0.065 g of the desired product. 1HNMR (DMSO-d6): δ 1.58 (s, 6H), 3.19 (s, 2H), 7.50-7.63 (m, 4H), 7.88 (m, 2H), 8.30 (d, J=4.2 Hz, 1H), 9.98 (s, 1H), 11.50 (br s, 1H), 12.70 (br s, 2H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08519149B2
Source datasetuspto-grants-2013_08
ORD IDord-3bbc1aed923a4ca289aad03a86abe933
Source noteuspto-grants-2013_08