Methanesulfonic Acid → 2-((3,5-Dichloropyridin-4-yl)amino)-N-(4-fluoro-3-(trifluoromethyl)phenyl)-7,7-dimethyl-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxamide Methanesulfonate

HRID 1898474Notes

Reaction equation

HRID 1898474 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:37])[C:7]=1[NH:8][C:9]1[NH:13][C:12]2[C:14]3[CH2:15][C:16]([CH3:36])([CH3:35])[O:17][C:18]=3[C:19]([C:21]([NH:23][C:24]3[CH:29]=[CH:28][C:27]([F:30])=[C:26]([C:31]([F:34])([F:33])[F:32])[CH:25]=3)=[O:22])=[CH:20][C:11]=2[N:10]=1.[CH3:38][S:39]([OH:42])(=[O:41])=[O:40]>CC(C)=O>[CH3:38][S:39]([OH:42])(=[O:41])=[O:40].[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:37])[C:7]=1[NH:8][C:9]1[NH:13][C:12]2[C:14]3[CH2:15][C:16]([CH3:35])([CH3:36])[O:17][C:18]=3[C:19]([C:21]([NH:23][C:24]3[CH:29]=[CH:28][C:27]([F:30])=[C:26]([C:31]([F:34])([F:32])[F:33])[CH:25]=3)=[O:22])=[CH:20][C:11]=2[N:10]=1

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 178422778HCID 178422778, compound

Product 1

HCID 1784227802-((3,5-Dichloropyridin-4-yl)amino)-N-(4-fluoro-3-(trifluoromethyl)phenyl)-7,7-dimethyl-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxamide Methanesulfonate

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

The title compound was prepared following the procedure described for Example-169 by using 2-((3,5-dichloropyridin-4-yl)amino)-N-(4-fluoro-3-(trifluoromethyl)phenyl)-7,7-dimethyl-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxamide (Example-196, 0.100 g), acetone, methanesulphonic acid to afford 0.051 g of the desired product. 1HNMR (DMSO-d6): δ 1.58 (s, 6H), 2.31 (s, 6H), 3.10 (s, 2H), 7.35 (s, m1H), 7.52 (t, J=9.9 Hz, 1H), 7.86 (m, 1H), 8.29 (m, 1H), 8.56 (s, 2H), 9.88 (s, 1H), 11-12.00 (br s, 4H).

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-d908db75c77d45e185e63df8bbc44d60
Source dataset
uspto-grants-2013_08
Patent number
US08519149B2

Reaction notes

Loading…