4-Fluoro-3-(trifluoromethyl)aniline → HCID 86664711, compound

Participants

Reaction Steps

The title compound was prepared following the procedure described for Example-143 by using methyl 2-((3,5-dichloropyridin-4-yl)amino)-1,7,7-trimethyl-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxylate (Intermediate-60, 0.100 g, 0.237 mmol), 4-fluoro-3-(trifluoromethyl) aniline (0.063 g, 0.356 mmol), trimethyl aluminium (2M solution in toluene) (0.5 mL), dry toluene (5.0 mL) to afford 0.070 g of the desired product. 1HNMR (DMSO-d6): δ 1.60 (s, 6H), 3.48 (s, 2H), 3.59 (s, 3H), 7.22 (s, 1H), 7.51 (t, J=9.9 Hz, 1H), 7.85-7.88 (m, 1H), 8.30 (m, 1H), 8.47 (s, 2H), 9.87 (s, 1H), 10.90 (s, 1H); MS [M]+: 568.03.

Provenance & Evidence