4-(Trifluoromethyl)aniline → HCID 67503296, compound

Participants

Reaction Steps

The title compound was prepared following the procedure described for Example-143 by using methyl 2-((3,5-dichloropyridin-4-yl)amino)-1,7,7-trimethyl-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxylate (Intermediate-60, 0.100 g, 0.237 mmol), 4-(trifluoromethyl) aniline (0.057 g, 0.356 mmol), trimethyl aluminium (2M solution in toluene) (0.5 mL), dry toluene (5.0 mL) to afford 0.075 g of the desired product. 1HNMR (DMSO-d6): δ 1.61 (s, 6H), 3.49 (s, 2H), 3.60 (s, 3H), 7.25 (s, 1H), 7.71 (d, J=8.1 Hz, 2H), 7.91 (t, J=8.1 Hz, 2H), 8.47 (s, 2H), 9.94 (s, 1H), 10.91 (s, 1H); MS [M+]+: 550.29.

Provenance & Evidence