4-Cyclopropylaniline → N-(4-Cyclopropylphenyl)-2-((3,5-dichloropyridin-4-yl)amino)-1,7,7-trimethyl-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxamide

Participants

Reaction Steps

The title compound was prepared following the procedure described for Example-143 by using methyl 2-((3,5-dichloropyridin-4-yl)amino)-1,7,7-trimethyl-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxylate (Intermediate-60, 0.100 g, 0.245 mmol), 4-cyclopropylaniline (Intermediate-50, 0.047 g, 0.356 mmol), trimethyl aluminium (2M solution in toluene) (0.5 mL), dry toluene (5.0 mL) to afford 0.045 g of the desired product. 1HNMR (DMSO-d6): δ 0.63 (m, 2H), 0.91 (d, J=6.6 Hz, 2H), 1.60 (s, 6H), 1.89 (m, 1H), 3.48 (s, 2H), 3.59 (s, 3H), 7.05 (d, J=7.8 Hz, 2H), 7.26 (s, 1H), 7.54 (d, J=8.1 Hz, 2H), 8.46 (s, 2H), 9.61 (br s, 1H), 10.88 (br s, 1H); MS [M−H]−: 520.06.

Provenance & Evidence