Trifluoroacetic acid → 1-((R)-2-amino-propionyl)-azetidine-3-carbonitrile trifluoroacetate

Participants

Reaction Steps

[(R)-2-(3-Cyano-azetidin-1-yl)-1-methyl-2-oxo-ethyl]-carbamic acid tert-butyl ester (1.05 g, 3.27 mmol) was dissolved in 4 mL of dichloromethane. The solution was cooled in an ice bath and 1.2 mL of trifluoroacetic acid was added slowly. After 1.5 h the reaction was concentrated to afford 1-((R)-2-amino-propionyl)-azetidine-3-carbonitrile trifluoroacetate which was used without further purification.

Provenance & Evidence