Trifluoroacetic acid → 3-Methylazetidine-3-carbonitrile; trifluoroacetic acid

Participants

Reaction Steps

3-Cyano-3-methyl-azetidine-1-carboxylic acid tert-butyl ester (0.23 g, 1.17 mmol) was dissolved in 12 mL of dichloromethane and the reaction was then stirred in an ice bath. Trifluoroacetic acid (3.6 mL) was added slowly and the solution was warmed to room temperature. After 3 h the reaction mixture was evaporated to afford 3-cyano-3-methyl-azetidine trifluoroacetate which was used without further purification.

Provenance & Evidence