HRID1898511

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID57516598

未命名化合物

结构：CCn1cc(-c2cnc3c(n2)c(C(=O)O)cn3COCC[Si](C)(C)C)cn1

HCID58438544

未命名化合物

结构：CC(C)(C)[C@@H](N)C(=O)N1CCC(F)(C#N)C1.O=C(O)C(F)(F)F

HCID67386183

未命名化合物

PRODUCTS

生成物

结构：CCn1cc(-c2cnc3[nH]cc(C(=O)N[C@@H](C(=O)N4CCC(F)(C#N)C4)C(C)(C)C)c3n2)cn1

HCID58438588

未命名化合物

PROCEDURE

实验过程

Prepared according to the procedure outlined in Example 1, steps 3-4 substituting 1-((R)-2-amino-3,3-dimethylbutanoyl)-3-fluoropyrrolidine-3-carbonitrile trifluoroacetate for (R)-2-amino-3,3-dimethyl-1-(pyrrolidin-1-yl)butan-1-one hydrochloride and 2-(1-ethyl-1H-pyrazol-4-yl)-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[3,2-b]pyrazine-7-carboxylic acid for 2-cyclopropyl-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2, 3-1)]pyrazine-7-carboxylic acid. MS: (M+H)+=467.

WORKUP

后处理

customPrepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-34de4c50bab245bab41d2975e0bc6041
来源数据集: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08518945B2
来源说明: uspto-grants-2013_08

反应 SMILES

FC(F)(F)C(O)=O.[NH2:8][C@H:9]([C:20]([CH3:23])([CH3:22])[CH3:21])[C:10]([N:12]1[CH2:16][CH2:15][C:14]([F:19])([C:17]#[N:18])[CH2:13]1)=[O:11].Cl.N[C@H](C(C)(C)C)C(N1CCCC1)=O.[CH2:38]([N:40]1[CH:44]=[C:43]([C:45]2[N:50]=[C:49]3[C:51]([C:62](O)=[O:63])=[CH:52][N:53](COCC[Si](C)(C)C)[C:48]3=[N:47][CH:46]=2)[CH:42]=[N:41]1)[CH3:39]>>[C:17]([C:14]1([F:19])[CH2:15][CH2:16][N:12]([C:10]([C@H:9]([NH:8][C:62]([C:51]2[C:49]3[C:48](=[N:47][CH:46]=[C:45]([C:43]4[CH:42]=[N:41][N:40]([CH2:38][CH3:39])[CH:44]=4)[N:50]=3)[NH:53][CH:52]=2)=[O:63])[C:20]([CH3:23])([CH3:22])[CH3:21])=[O:11])[CH2:13]1)#[N:18]