Hydrochloric Acid → 4-Methylpiperidine-4-carbonitrile--hydrogen chloride (1/1)

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Reaction Steps

In a round-bottomed flask, 4-cyano-4-methyl-piperidine-1-carboxylic acid tert-butyl ester (0.35 g, 1.56 mmol) was dissolved in hydrogen chloride, 1.0 M solution in methanol (9.0 mL, 9.00 mmol). The reaction mixture was stirred at room temperature overnight then concentrated to give 0.27 g of 4-methyl-piperidine-4-carbonitrile hydrochloride as an off-white foam which was used without further purification.

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