HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrrolidine → HCID 58438592, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | (2R)-2-{[(tert-butoxy)carbonyl]amino}-3,3-dimethylbutanoic acid | HCID 7005057 | — |
| Reactant | (R)-2-((tert-Butoxycarbonyl)amino)-2-cyclopropylacetic acid | HCID 7146275 | — |
| Reactant | 4-(Trifluoromethyl)-4-piperidinol | HCID 17951321 | — |
| Reactant | 2-cyclopropyl-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid | HCID 57829653 | — |
| Reactant | 2-(1-ethyl-1H-pyrazol-4-yl)-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[3,2-b]pyrazine-7-carboxylic acid | HCID 58438544 | — |
| Product | HCID 58438592 | HCID 58438592 | — |
Reaction Steps
Prepared according to the procedure outlined in Example 1 substituting 4-trifluoromethyl-piperidin-4-ol (Example 74, step 2) for pyrrolidine, Boc-D-cyclopropyl glycine for Boc-D-tert-leucine, and 2-(1-ethyl-1H-pyrazol-4-yl)-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[3,2-b]pyrazine-7-carboxylic acid for 2-cyclopropyl-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid. MS: (M+H)+=506.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08518945B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-5c958fbf81774b98b9280c71fae8e98d |
| Source note | uspto-grants-2013_08 |