Propylamine → 6-hydroxy-2,5,7,8-tetramethyl-N-propylchroman-2-carboxamide

HRID 1898678Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1898678
[OH:1][C:2]1[C:3]([CH3:18])=[C:4]2[C:9](=[C:10]([CH3:13])[C:11]=1[CH3:12])[O:8][C:7]([CH3:17])([C:14]([OH:16])=O)[CH2:6][CH2:5]2.C1N=CN(C(N2C=NC=C2)=O)C=1.[CH2:31]([NH2:34])[CH2:32][CH3:33]>>[OH:1][C:2]1[C:3]([CH3:18])=[C:4]2[C:9](=[C:10]([CH3:13])[C:11]=1[CH3:12])[O:8][C:7]([CH3:17])([C:14]([NH:34][CH2:31][CH2:32][CH3:33])=[O:16])[CH2:6][CH2:5]2

Komponenten

4

Edukt 3

HCID 7852PropylamineHCID 40634TroloxHCID 682631,1'-Carbonyldiimidazole

Produkt 1

HCID 672629696-hydroxy-2,5,7,8-tetramethyl-N-propylchroman-2-carboxamideAusbeute 63,3 %

Versuchsvorschrift

Following the amide coupling procedure described in protocol A, 502.3 mg 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (2.01 mmol), 358 mg CDI (2.21 mmol) and 130 mg propylamine (2.20 mmol) produced 371 mg of 6-hydroxy-2,5,7,8-tetramethyl-N-propylchroman-2-carboxamide as an off white syrup.

Quellen und Nachweise

ORD-Eintrag
ord-fc0cfc3788f645bfbcc17ac8ba8e4796
Quelldatensatz
uspto-grants-2013_08
Patentnummer
US08519001B2

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