HuagongsheHuagongshe Chemistry Print Report · For research reference only
Citric Acid → HCID 67262986, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Citric Acid | HCID 311 | — |
| Reactant | Hexylamine | HCID 8102 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | HCID 11001420 | HCID 11001420 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 67262986 | HCID 67262986 | — |
Reaction Steps
To one of the above aliquots of crude 2-(chlorocarbonyl)-2,5,7,8-tetramethylchroman-6-yl acetate in 10 mL CH2Cl2 was added 1.0 mL diisopropylethylamine followed by 315 mg 1-hexylamine and overnight stiffing. The reaction mixture was poured into 1.0 M citric acid and 50 mL EtOAc added. The organic layer was separated and purified by flash chromatography to give 781 mg of 2-(hexylcarbamoyl)-2,5,7,8-tetramethylchroman-6-yl acetate, as a clear syrup. MS (m/z): M+376.3
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08519001B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-7adab3c017b04a5ba50a23cc1603832a |
| Source note | uspto-grants-2013_08 |