反应详情

45 g (0.168 mol) of diethyl 5-nitropyridine-2,3-dicarboxylate were added in the course of 10 minutes with stirring to a mixture of 13.4 g (0.336 mol) of sodium hydroxide in 65 ml of water and washed in with 6.5 ml of ethanol. The mixture was brought to reflux, diluted with a further 30 ml of water and cooled again after heating for 1 hour. The precipitate deposited after the addition of 500 ml of acetone was filtered off with suction, washed and dried, 42.4 g (98.6% of theory) of sodium 5-nitropyridine-2,3-dicarboxylate of m.p.>260° C. being obtained.

1. washwashed in with 6.5 ml of ethanol
2. temperatureto reflux
3. additiondiluted with a further 30 ml of water
4. temperaturecooled again
5. temperatureafter heating for 1 hour
6. additionafter the addition of 500 ml of acetone
7. filtrationwas filtered off with suction
8. washwashed
9. customdried