Dimethylformamide → HCID 15451778, compound

Participants

Reaction Steps

6.3 g (0.0254 mol) of N-1-(cyclopropyl)ethyl-6-fluoro-5-methylpyridine-2,3-dicarboximide and 4.1 g (0.051 mol) of potassium cyanate were introduced into a mixture of 50 ml of DMF and 1 ml of water at 25° C. with stirring and then stirred at 125° C. for 30 minutes. After concentrating the reaction mixture under reduced pressure, the residue was stirred in succession with methyl tert-butyl ether and with water. Insoluble matter was filtered off with suction, washed with methyl tert-butyl ether and dried under reduced pressure. 3.5 g (56% of theory) of the title compound of m.p. 219°-220° C. were obtained. A further 1.6 g (=26% of theory) of the title compound of m.p. 201°-219° C. were obtained from the organic phase after washing with water and drying over magnesium sulfate (active compound Example 1.059).

Provenance & Evidence