Water → HCID 23372626, compound

Participants

Reaction Conditions

Reaction Steps

A stirred mixture of 1.66 g (0.010 mol) of 4-methoxycarbonyl-o-phenylene-diamine and 1.58 g (0.010 mol) of 2-chloronicotinic acid in 5 ml of 2-butoxyethanol was heated to 140° C. for 2 h, during which time a dark solution, followed by formation of a green solid, was observed. The reaction mixture was poured into 50 ml of water and the solid collected and stirred in 10% sodium carbonate solution for 1 h. The resulting solid was collected, washed thoroughly with water, dried and crystallized from DMF to yield 1.1 g (40% of theory) of a beige crystalline product, m.p. 344°-349° C.

Provenance & Evidence