2-Chloronicotinic acid → HCID 13776180, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-chloronicotinic acid (15.7 g, 0.1 mol) and 4-nitrophenylene diamine (15.3 g, 0.1 mol) was heated in sulfonane (100 ml) at 170° C. for 5 hrs. The reaction mixture was then cooled and left standing overnight. The solid material was filtered and taken up in boiling ethanol. The solid was filtered again an dried giving 21 g (82% theory) of 6,11-dihydro-9-nitro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one suitable for use in the next reaction.

Provenance & Evidence