Ammonia → 4-tert-Butylcyclohexylamine

HRID 1898887Notes

Reaction equation

HRID 1898887 reaction equation
[C:1]([CH:5]1[CH2:10][CH2:9][C:8](=O)[CH2:7][CH2:6]1)([CH3:4])([CH3:3])[CH3:2].[NH3:12]>[Ni]>[C:1]([CH:5]1[CH2:10][CH2:9][CH:8]([NH2:12])[CH2:7][CH2:6]1)([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 73924-tert-Butylcyclohexanone

Product 1

HCID 793964-tert-Butylcyclohexylamine

Reagents, catalysts & solvents 1

HCID 935NickelCatalyst

Procedure

312 g of 4-tert-butylcyclohexanone in 500 ml of ammonia-saturated methanol were hydrogenated at 100° C. and 100 bar in the presence of 10 g of Raney nickel. The catalyst was filtered off, the mixture was concentrated, and the crude product was purified on a thin-layer evaporator (105°/0.5 mm). 303 g of colorless liquid were obtained. The product is an isomer mixture in which the cis-cyclohexylamine derivative prevails. ##STR11##

Workup

  1. customwere hydrogenated at 100° C.
  2. filtrationThe catalyst was filtered off
  3. concentrationthe mixture was concentrated
  4. customthe crude product was purified on a thin-layer evaporator (105°/0.5 mm)

Sources & evidence

ORD record
ord-51b6a337690d4903814639a2d72328e2
Source dataset
uspto-grants-1996_11
Patent number
US05571815

Reaction notes

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