Thiourea → HCID 178436981, compound

HRID 1898895Notes

Reaction equation

HRID 1898895 reaction equation
Cl[C:2]1[N:7]2[N:8]=[CH:9][CH:10]=[C:6]2[N:5]=[C:4]([CH2:11][CH3:12])[CH:3]=1.NC(N)=[S:15]>C(O)C>[CH2:11]([C:4]1[CH:3]=[C:2]([SH:15])[N:7]2[N:8]=[CH:9][CH:10]=[C:6]2[N:5]=1)[CH3:12]

Participants

4

Reactant 2

HCID 2723790ThioureaHCID 105354107-Chloro-5-ethylpyrazolo[1,5-a]pyrimidine

Product 1

HCID 178436981HCID 178436981, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

5.0 g (27.5 mmol) of the chloride from Example 1, Step B and 4.2 g (55.2 mmol) thiourea were heated in 100 ml dry ethanol for 5 h. The solvent was distilled off in vacuo and the residue crystallized from ethanol/water to give the title compound in yellow crystals, m.p. 178°-180° C.

Workup

  1. distillationThe solvent was distilled off in vacuo
  2. customthe residue crystallized from ethanol/water

Sources & evidence

ORD record
ord-4d8e52d732e74a8c80c9111495ab523a
Source dataset
uspto-grants-1996_11
Patent number
US05571813

Reaction notes

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