反应详情

5.7 g (30.3 mmol) 5,7-dichloropyrazolo[1,5-a]pyrimidine (prepared according to T. Novinson, B. Bhooshan, T. Okabe, G. R. Revankar, R. K. Robins, K. Senga, H. R. Wilson, J. Med. Chem. 1976, 19, 512) and 6.3 g (30.25 mmol) 4-aminomethyl-2'-cyanobiphenyl were dissolved in 150 ml dry ethanol and heated with reflux for 10 h. The solvent was removed in vacuo, the residue dissolved in ethyl acetate, washed with 10% aqueous sodium carbonate solution, and dried over sodium sulfate. After evaporation in vacuo the title compound crystallized from ethyl acetate/ether in colorless crystals, m.p. 162°-163° C.

1. temperatureheated
2. temperaturewith reflux for 10 h
3. customThe solvent was removed in vacuo
4. dissolutionthe residue dissolved in ethyl acetate
5. washwashed with 10% aqueous sodium carbonate solution
6. dry with materialdried over sodium sulfate
7. customAfter evaporation in vacuo the title compound
8. customcrystallized from ethyl acetate/ether in colorless crystals, m.p. 162°-163° C.