Oxalic Acid → HCID 53697363, compound

Participants

Reaction Steps

A mixture of 4.084 g (10 mmol) of a compound II (R1 =CH3 ; R2, R3, R5, R6 =H; R4 =C2H5), 360 mg (4 mmol) of anhydrous oxalic acid and 9 ml of glacial acetic acid was stirred at 60° for 3 hours and then worked up as described in Example 5. 2.83 g (69.3% yield) of pure 4-amino-2-(4-methyl-2-oxo-1-imidazolidinyl)pyrimidine-5-carboxylic acid N-ethyl-N-(3-trifluoromethylphenyl)amide were obtained (by crystallization from ether) after drying, melting point 208°-209°.

Provenance & Evidence