Nitric Acid → HCID 67769393, compound

Participants

Reaction Steps

2.05 ml of a molar solution of HNO3 in ethyl acetate were added to a suspension of 881 mg (2 mmol) of 4-amino-2-(4,4-dimethyl-2-oxo-1-imidazolidinyl)pyrimidine-5-carboxylic acid N-ethyl-N-(2-fluoro-5-trifluoromethylphenyl)amide (compound I from Example 17) in 13.3 ml of ethyl acetate at room temperature. This briefly resulted in a solution, from which a crystalline substance separated out. The latter was, after stirring (in an ice bath) for 1 hour, filtered off with suction, washed with ethyl acetate and ether and dried at 80° in vacuo (6-8 mbar) for 15 hours. 1.02 g of 4-amino-2-(4,4-dimethyl-2-oxo-1-imidazolidinyl)pyrimidine-5-carboxylic acid N-ethyl-N-(2-fluoro-5-trifluoromethylphenyl)amide nitrate were obtained, melting point 235°-236°. This nitrate is soluble in a concentration of 1.7% by weight in water, i.e. 1 part dissolves in 57.5 parts of water.

Provenance & Evidence